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We conclude that daunorubicin interacts with red blood cells in a manner that increases phosphatidylserine exposure and consequent procoagulant activity Lactadherin acts as an efficient anticoagulant in this process. Lactadherin is an efficient anticoagulant of this process.

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The present study aims to evaluate the possible impact of daunorubicin on phosphatidylserine exposure and consequent procoagulant property of red blood cells. Our results demonstrate that daunorubicin treatment enhanced pca of huvecs through ps exposure and shedding of procoagulant emps Theprocoagulant property of red blood cells was not affected by the other three agents

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The modulating effect ofprocoagulant activity was concomitant with and dependent on level of phosphatidylserine on the outersurface.

Red blood cells (rbcs), the most abundant blood cells in circulation, also play an active role in the process of thrombus formation However, the effect of hcy on procoagulant activity (pca) of rbcs is unclear. Our study aims to investigate the possibility that daunorubicin, a chemotherapeutic agent, exerts prothrombotic effect on endothelial cells We tested the impact of daunorubicin on phosphatidylserine (ps) exposure, endothelial microparticles (emps) release and consequent pca.

We conclude that daunorubicin interacts with red blood cells in a manner that increases phosphatidylserine exposure and consequent procoagulant activity. Moreover, daunorubicin treatment also enhanced the release of emps which were highly procoagulant.